Impaired dynamics and function of mitochondria caused by mtDNA toxicity

Impaired dynamics and function of mitochondria caused by mtDNA toxicity 1 leads to heart failure 2 3 Knut H. Lauritzen*, Liv Kleppa, Jan Magnus Aronsen, Lars Eide, Harald Carlsen, 4 Øyvind P. Haugen, Ivar Sjaastad, Arne Klungland, Lene Juel Rasmussen, Håvard 5 Attramadal, Jon Storm-Mathisen, and Linda H. Bergersen* 6 7 a Brain and Muscle Energy Group, Department of Oral Biology, University of Oslo, Oslo, 8 Norway 9 b Department of Anatomy, Institute of Basic Medical Sciences, and Healthy Brain Ageing Centre, 10 University of Oslo, Oslo, Norway 11 c Institute for Experimental Medical Research, Oslo University Hospital Ullevål and University of 12 Oslo, Oslo, Norway 13 d KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, 14 Norway, Oslo, Norway 15 e Department of Medical Biochemistry, University of Oslo, Oslo, Norway 16 f Department of Nutrition Research, Institute of Basic Medical Sciences, University of Oslo, 17 Oslo, Norway 18 g Institute of Medical Microbiology, Oslo University Hospital, Oslo, Norway 19 h Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark 20 i Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark 21 j Institute for Surgical Research, Oslo University Hospital, Oslo, Norway 22 k Center for Heart Failure Research, University of Oslo, Oslo, Norway 23 24 Running title: Toxic mtDNA gives mitochondriopathic heart failure 25 26 ¶ Equal contribution 27 § Jan Magnus Aronsen is presently at Bjørknes College, Oslo, Norway 28 * Correspondence to: 29 Linda H. Bergersen or Knut H. Lauritzen at Brain and Muscle Energy Group, Department of Oral 30 Biology, University of Oslo, POB 1052 Blindern, 0316 Oslo, Norway. Tel.: +47 970 32 049 or 31 +47 416 47 410. 32 E-mail addresses: [email protected], [email protected] 33 34 Articles in PresS. Am J Physiol Heart Circ Physiol (June 8, 2015). doi:10.1152/ajpheart.00253.2014